Endocrine Abstracts

Metabolic diseases represent a threatening worldwide epidemic that affects the entire body. It is known that metabolic diseases, namely diabetes, and obesity affect spermatogenesis via suppressing testosterone synthesis, inducing oxidative stress and other changes that lead to decreased male fertility. Glucagon-like peptide 1 (GLP1) receptor agonists, like liraglutide, are pharmacological agents recommended to normalize glucose levels in patients with type 2 diabetes mellitus....

Diabetic nephropathy (DN) and insulin resistance (IR) in kidney cells are considered the main cause of end-stage renal failure. Additionally, hyperglycemia and increased fatty (FA) acids are observed in patients with type 2 diabetes mellitus, where lipid accumulation has been correlated to IR. Nonetheless, the impact of IR in early disease stages is still unclear. Moreover, proximal renal tubular cells have high mitochondrial content where aerobic respiration is their primary ...